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Vesiculovirus matrix proteins
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Vesiculovirus matrix proteins : ウィキペディア英語版
Vesiculovirus matrix proteins

The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. The matrix (M) protein of the virus causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.
==Function==
These proteins play a major role in assembly and budding of VSIV virions. Their main role is to aid virus assembly. They starts by shutting off host cell transcription by inhibiting mRNA nuclear export through direct interaction with the host RAE1-NUP98 complex. This inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. In turn, this induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell. Enveloped viruses acquire their membrane by budding at a membrane of their host cell.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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